The role of PD1 pathway on tolerance after allogeneic transplantation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591425
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Okayama University
• Principal Investigator: TANIMOTO Mitsune 岡山大学, 医歯(薬)学総合研究科, 教授 (10240805)
• Co-Investigator(Kenkyū-buntansha): MAEDA Yoshinobu 岡山大学, 岡山大学病院, 講師 (60403474)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: GVHD

Outline of Final Research Achievements

The results of this study show that the PD-1 pathway is important in the alleviation of chronic GVHD. Blockade of the PD-1 pathway using anti PD-1, anti PD-L1, or anti PD-L2 mAbs exacerbated chronic GVHD, and chimeric mice showed the importance of PD-L1 expression in host tissues in attenuating chronic GVHD. BMT into PD-L1 deficient recipients revealed IL-17+IFN-gamma+ T cell expansion and Am80 administration of Am80 overcame the IL-17+IFN-gamma+ T cell expansion caused by PD-L1 deficiency, resulting in reduced chronic GVHD damage in PD-L1 deficient recipients. Stimulation of the PD-1 pathway with an agonistic anti PD-1 mAb alleviated chronic GVHD, suggesting a new target for the prevention or treatment of chronic GVHD.

Free Research Field

移植免疫