Analysis of monocytes involved in joint destruction and joint repair in rheumatoid arthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591455
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo Dental College (2014); Keio University (2012-2013)
• Principal Investigator: SETA noriyuki 東京歯科大学, 歯学部, 准教授 (40338372)
• Co-Investigator(Kenkyū-buntansha): KUWANA Masataka 慶應義塾大学, 医学部, 准教授 (50245479)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 関節リウマチ / 末梢血単球

Outline of Final Research Achievements

The number of circulating CD14+CD15-CXCR4high monocytes (Mos) possibly involved in joint repair in RA decreased in RA patients compared with that in healthy donors. Moreover, the expression of IL-6, TNF alpha, and CCR5 were high in CD14+CD15+CXCR4low Mos possibly involved in joint destruction in RA, and the expression of CX3CR1 was high in CD14+CD15-CXCR4high Mos, indicating that these cell groups may be controled by different factors. Furhtermore, the number of circulating CD14brightCD16- (classical) Mos decreased in RA patients compared with that in healthy donors, and classical Mos were decreased in RA patients with a response to methotrexate after treatment. These results indicate that classical Mos also may involve in the joint destruction.

Free Research Field

リウマチ学