2014 Fiscal Year Final Research Report
The role of RAGE for allergic airway responses
| Project/Area Number |
24591463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEHIRO Arihiko 岡山大学, 大学院医歯薬学総合研究科, 准教授 (20243503)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 気管支喘息 / RAGE |
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| Outline of Final Research Achievements |
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor which belongs to the immunoglobulin superfamily. RAGE is reported to be involved in various inflammatory disorders, however, studies that address the role of RAGE in allergic airway disease are inconclusive. RAGE sufficient (RAGE+/+) and RAGE deficient (RAGE-/-) mice were sensitized to ovalbumin (OVA), and airway responses were monitored after OVA challenge. RAGE-/- mice showed reduced eosinophilic inflammation and goblet cell metaplasia, lower T helper type 2 (Th2) cytokine production from spleen and peribronchial lymph node mononuclear cells, and lower numbers of group 2 innate lymphoid cells (ILC2s) in the lung compared to RAGE+/+ mice following sensitization and challenge. Thus, manipulating RAGE represents a novel therapeutic target in controlling allergic airway responses.
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| Free Research Field |
気管支喘息
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