Trial in the regulation of mast cell function by targeting autophagy related protein

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Juntendo University
• Principal Investigator: USHIO HIROKO 順天堂大学, 医学(系)研究科(研究院), 准教授 (30317391)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: マスト細胞 / オートファジー / 顆粒形成

Outline of Final Research Achievements

Autophagy is the essential function for controlling various biological responses including starvation, homeostatic turnover of long-lived proteins, and invasion of bacteria. However, a role for autophagy in the development and function of mast cells is largely unknown. We recently have reported that autophagy-related gene (Atg) 7, a critical enzyme for autophagosome formation, has relevance of mast cell functions using bone marrow-derived mast cells (BMMCs) from Atg7-deficient mice. To define further the roles for autophagy in mast cell function, we analyzed the changes of Atgs in mast cells after IgE-mediated activation using PCR-array. We found further that Atg9b, Gamma-aminobutyric acid A receptor-associated protein-like 1 (GABARAPL1), a homolog of Atg8, were also associated in the degranulation and regranulation of mast cells. Collectively, these results may lead to help modifing the mast cell function by targeting these proteins.

Free Research Field

アレルギー