Regulation of dendritic cell function by coagulation factors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591472
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kansai Medical University
• Principal Investigator: ITO Tomoki 関西医科大学, 医学部, 准教授 (70434826)
• Co-Investigator(Kenkyū-buntansha): NOMURA Shosaku 関西医科大学, 医学部, 教授 (20218358)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 樹状細胞 / 血小板 / アレルギー / CCL17 / RANKリガンド

Outline of Final Research Achievements

There is an intimate link between the “immune-inflammatory response” and the “coagulation-fibrinolytic response”, which mutually interfere with each other. Platelets as coagulation factors are also potent immune cells that promote the inflammatory process through the expression of a wide variety of cytokines, chemokines, and TNF superfamilies. Platelets have the ability to enhance the DC-mediated Th2 response through RANK ligand expression and contribute to the allergic inflammation induced by DCs. Our study provides new insights in platelet functions and the possible mechanism of allergic responses that stem from DCs, and therefore, platelets would be a new therapeutic targets for the treatment of allergic disorders.

Free Research Field

血液免疫学