2014 Fiscal Year Final Research Report
Understanding of interaction between immunological and non-immunological mechanisms for development of atopic dermatitis
| Project/Area Number |
24591474
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YASUDA Takuwa 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00373374)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アトピー性皮膚炎 / 好塩基球 |
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| Outline of Final Research Achievements |
In this study, using a newly generated mutant mouse (Spade mouse), which spontaneous develops atopic dermatitis like skin disease, we investigated a responsible cells and factors for development of dermatitis.
Our data showed that basophils played a pivotal role in development of dermatitis in our Spade mouse model. Our results suggested that basophils were activated by TSLP and/or IL-33, and then, basophils secreted IL-4 and IL-13, those induced allergic responses directly or regulated inflammatory cells such as eosinophils, neutrophils and macrophages.
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| Free Research Field |
免疫学・アレルギー学
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