2014 Fiscal Year Final Research Report
Development of a panel of neutralizing monoclonal antibodies aiming toward HIV cure
Project/Area Number |
24591484
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | HIV-1 / エンベロープ蛋白 / 交差中和抗体 / ADCC / 免疫学 / ウイルス / 感染防御学 / 免疫学 |
Outline of Final Research Achievements |
HIV-1infection/AIDS became a controllable disease following continuous advancement of combination antiretroviral therapy (cART). However, pathogenic process that is caused by residual viral replication under effective cART has been noticed as a major problem in the long-term control of HIV-1 infected patients. In this study we established assay system to measure antibody-dependent cell-mediated cytotoxicity (ADCC) aiming toward elimination of HIV-1 infected cell using a panel of neutralizing monoclonal antibodies and identified the antibody response that is effective for ADCC. We also found a patient who had broad neutralizing activity against 22 pseudoviruses of 7 different subtypes and identified epitope recognized by the antiserum in V2/V3 region of gp120.
|
Free Research Field |
血液内科学
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