2014 Fiscal Year Final Research Report
Development of novel entry inhibitors with inducing conformational change of Non-B HIV-1 envelope.
| Project/Area Number |
24591485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | HIV-1 / entry inhibitors / Betulinic acid / envelope |
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| Outline of Final Research Achievements |
We found many novel entry inhibitors (Betulinic acid analogues) that could inhibit infection of HIV-1. We also found that combinations of the Betulinic acid analogues with anti-gp120 MAbs showed synergistic interactions against HIV-1 not only subtype B but also subtype non-B. These findings suggest that small compounds such as Betulinic acid analogues may enhance the neutralizing activities of CD4i and anti-V3 Abs in vivo.
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| Free Research Field |
ウイルス学
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