2014 Fiscal Year Final Research Report
Development of new treatment strategies for HIV -1 infection
| Project/Area Number |
24591486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
HAMADA Koichi 昭和薬科大学, 薬学部, 助教 (00343070)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ＨＩＶ－１ / 潜伏感染 / ＰＩ３Ｋ／ＰＴＥＮ |
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| Outline of Final Research Achievements |
The presence of latent vial infection has prevented the eradication of human immunodeficiency virus (HIV) from infected patients successfully treated with anti-retroviral therapy. Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir is impervious to cART and represents a major barrier to curing HIV-1 infection.
PI3K/PTEN/GSK-3β pathway is a critical role for cell proliferation and survival. In this study, we identified that PI3K/PTEN/GSK-3β pathway is necessary to HIV infection and reactivation.
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| Free Research Field |
ウイルス学
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