2014 Fiscal Year Final Research Report
Study of mechanism and control of bacterial translocation from the gastrointestinal tract
| Project/Area Number |
24591491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | バクテリアル・トランスロケーション / 腸内細菌 / プロバイオティクス |
|---|
| Outline of Final Research Achievements |
Bacterial translocation (BT) is defined as the passage of viable bacteria from the gastrointestinal tract to extraintestinal sites via lymphatic and/or blood vessel routes. We studied the mechanisms of BT by using immunosuppressive mouse model with cyclophosphamide treatment and the results showed intragastric administration of Pseudomonas aeruginosa frequently cause systemic spread of translocating bacteria to cause lethal sepsis. Administration of ampicillin induced exacerbation of BT and sepsis.
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| Free Research Field |
感染症
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