2016 Fiscal Year Final Research Report
Electroencephalogram analysis regarding pathophysiological mechanisms of epileptic cognitive disorders in childhood
| Project/Area Number |
24591513
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINAGA Harumi 国立病院機構南岡山医療センター, 特命副院長 (00230780)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | てんかん性脳症 / 脳波異常 / 高周波振動 |
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| Outline of Final Research Achievements |
In childhood epileptic encephalopathy in which epileptic activity itself may contribute to severe cognitive and behavioral impairments, we have detected an enormous amount of high-frequency/fast oscillations (HFOs/FOs) with frequencies far beyond the traditional limit from scalp electroencephalogram (EEG) data. We found that epileptic FOs represent disease severity in West syndrome and that intensity of epileptic HFOs corresponds to the degree of EEG abnormalities in various childhood epilepsies with spikes during sleep. It was thus indicated that stormy generation of pathological HFOs/FOs might cause impairment of higher brain functions by interfering with physiological high-frequency brain activity related to cognition.
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| Free Research Field |
小児神経学
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