2014 Fiscal Year Final Research Report
The role of bdnf on the development of the nervous system of slective-attension: from view points related to autistic spectrum disorders
| Project/Area Number |
24591519
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Shoei 岐阜薬科大学, 薬学部, 教授 (90159129)
SOUMIYA Hitomi 岐阜薬科大学, 薬学部, 助教 (20548713)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脳由来神経栄養因子 / 選択的注意 / 情動機能 / 自閉症スペクトラム障害 |
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| Outline of Final Research Achievements |
Several signaling-molecule genes for brain-derived neurotrophic factor (bdnf) have been known as risk factors of autistic spectrum disorders and the social-related behavioral abnormalities. In this study, we found that significant deficits in the social behaviors of bdnf heterozygous knock out (bdnf+/-) mice. Further investigations revealed that whisker tactile sensation, important for social behaviors, were comparable in bdnf+/- and wild-type mice; however bdnf+/- mice had learning disabilities of whisker-cued maze task and that hyperactivities in limbic systems of bdnf+/- mice were significantly increased comparing to those of wild-type when induced by height-stress. These functional abnormalities in the brain would affect the social behavior of bdnf-deficient mice.
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| Free Research Field |
神経科学
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