2014 Fiscal Year Final Research Report
Study of immuno-pathophysiology and application for treatment in non-herpetic acute limbic encephalitis: origin of autoantigens and subclass of antibodies
| Project/Area Number |
24591537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders |
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Principal Investigator |
TAKAHASHI Yukitoshi 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (70262764)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | GluN2B / GluN1 / 自己抗体 / IgGサブクラス / Fas / FasL |
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| Outline of Final Research Achievements |
Non-herpetic acute limbic encephalitis is the encephalitis related with antibodies to NMDA-type GluRs, which have important roles in CNS function. We have not revealed the immunopathology for production of antibodies to NMDA-type GluRs. In this study, we found that antigens for the antibodies derived from NMDA-type GluRs expressed on surface of lymphocytes and platelets in sera and CSF. We developed the quantitative measurement of IgG subclass of antibodies to GluN2B-NT2, and found that quantity of IgG3 subclass was related with sequelae, e.g. epilepsy, cognitive dysfunction, motor disturbance.
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| Free Research Field |
神経免疫学
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