Analysis of relationship between biological clock genes and environments for development of allergic diseases, and clinical application

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591545
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Gifu University
• Principal Investigator: KONDO naomi 岐阜大学, 医学(系)研究科(研究院), 名誉教授 (50124714)
• Co-Investigator(Kenkyū-buntansha): KATO Zenichiro 岐阜大学, 医学系研究科, 教授 (90303502) ; MATSUI Eiko 岐阜大学, 医学部附属病院, 講師 (90334929) ; KIMURA Takeshi 岐阜大学, 医学部附属病院, 助教 (60422705)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 体内時計遺伝子 / アレルギー関連遺伝子 / アレルギー発症 / 環境因子 / テーラーメイド医療

Outline of Final Research Achievements

The aim of this study is (1) analysis of relationship among allergic genes and biological clock genes and environments, and (2) establishment of an epoch-making prevention and treatment for allergic diseases.
As results, (1) expressions of biological clock genes (eq. CLOCK gene) were changeable during day and night, and production of interferon (IFN)-gannma that suppresses allergic reactions was suppressed by pH change. (2) The binding mode between interleukin (IL-18) and IL-18 receptor became clear, and then development of new medicines that are able to regulate IL-18 signaling was started for allergic diseases.

Free Research Field

小児、アレルギー