2014 Fiscal Year Final Research Report
Elucidation of the N- cadherin molecular mechanism in the leukemia microenvironment in bone marrow and the central nervous system
| Project/Area Number |
24591546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Masahiro 三重大学, 医学系研究科, 准教授 (90293795)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | N-カドヘリン / 白血病微小環境 / 急性白血病 |
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| Outline of Final Research Achievements |
N-cadherin, a family of Ca2+-dependent intercellular adhesion molecules, plays key roles in controlling morphogenetic movements during development and hematopoiesis in bone marrow (BM). Recently, it has been reported that this molecule might be associated with drug resistance in adult leukemia. Then we studied the clinical significance of N-cadherin in BM niche in acute childhood leukemia.
We found that N-cadherin was highly expressed on primary / hTERT immortalized BM stroma cells (BMSCs). Several kinds of leukemic cell lines and primary childhood leukemia cells also expressed different levels of N-cadherin. In addition, drug sensitivity in leukemic cells for anti-leukemic agents in co-culture system between leukemic cells and BMSCs increased in the presence of GC-4 antibody that can inhibit N-cadherin adherens junction formation .Taken together, these results supported that N-cadherin might be related to drug resistance in childhood acute leukemic cells in BM microenvironments.
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| Free Research Field |
小児血液腫瘍学
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