2014 Fiscal Year Final Research Report
novel treatment for neuroblastoma by live-attenuated poliovirus
| Project/Area Number |
24591547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
TOYODA Hidemi 三重大学, 医学(系)研究科(研究院), 助教 (60525327)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経芽腫 / ポリオウイルス |
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| Outline of Final Research Achievements |
The prognosis of neuroblastoma patients is poor. Thus, to develop a novel treatment is necessary. Our previous studies show that poliovirus has strong anti-neuroblastoma effects both in vitro and in vivo, and anti-neuroblastoma immune response was induced in neuroblastoma cured mice. In accordance with these findings, we started phase 1 clinical trial for relapse and refractory neuroblastoma patients. We have treated two relapsed neuroblastoma patients so far.
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| Free Research Field |
小児血液腫瘍
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