2014 Fiscal Year Final Research Report
Identification and characterization of novel human hematopoietic stem cell populations using the micro-RNA sensor vector
| Project/Area Number |
24591549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 造血幹細胞 / マイクロRNA |
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| Outline of Final Research Achievements |
The characterization of human hematopoietic stem cells (HSCs) will facilitate the hematopoietic cell therapy such as bone marrow transplantation. Although the human HSCs have been identified by the expression of distinct surface markers, we have identified a microRNA, miR-126, is highly expressed and has an important role in human HSCs. We have developed a new system, which allows us to identify the cells with miR-126 expression and found a new population that might have a new hematopoietic stem cell activity. Further characterization of this population is under investigation.
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| Free Research Field |
小児血液
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