2014 Fiscal Year Final Research Report
Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapy
Project/Area Number |
24591558
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Nara Medical University |
Principal Investigator |
NOGAMI KEIJI 奈良県立医科大学, 医学部, 准教授 (50326328)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 血液凝固 / 第Ⅷ因子 / 蛋白相互作用 / 出血性疾患 |
Outline of Final Research Achievements |
Factor VIII (FVIII) is an important key factor on blood coagulation in the opposite conditions such as the hemorrhages and thrombi. However, there are still uncertain points on FVIII-based (anti-)coagulation and thrombus formation. The conventional researches of blood coagulation had been fully done separately by the intrinsic and extrinsic pathway, anti-coagulant pathway, and fibrinolytic pathway, but it is being now supported that all pathways simultaneously participate and progress in coagulation. In this study, we found the relationship of FVIII(a) with thrombin and FIXa (intrinsic factors), FVIIa/tissue factor (extrinsic factor), plasmin (fibrinolytic factor), protein S (anti-coagulant factor), neutrophil proteinase 3 (inflammatory factor) during the blood coagulation process.
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Free Research Field |
医歯薬, 内科系臨床医学, 小児科学, 血液止血血栓学
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