2014 Fiscal Year Final Research Report
Establishment of immune torelance induction therapy for FVIII inhibitors by subcutaneous implantation of blood outgrowth endothelial cells
| Project/Area Number |
24591559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nara Medical University |
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Principal Investigator |
MATSUI HIDETO 奈良県立医科大学, 医学部, 講師 (00571027)
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| Co-Investigator(Renkei-kenkyūsha) |
HOTTA Akitsu 京都大学, 助教 (50578002)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 血友病 / インヒビター / 細胞移植 / 免疫寛容 / 制御性T細胞 |
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| Outline of Final Research Achievements |
The levels of FVIII inhibitors began to decline within 6 weeks after subcutaneous BOECs implantation and finally, the inhibitor levels had declined less than 5 BUs after the multiple implantations of transduced BOECs.The significant numbers of CD4+ CD25+ Foxp3 regulatory T cells were detected in spleen and draining lymph nodes of these partially tolerized mice and these suppressive effects against cFVIII could be adoptively transferred to naïve hemophilia recipient mice. We show that FVIII releasing subcutaneous depots play an important role of immunomodulatory effects that have a potential to reduce the levels of anti-FVIII inhibitor titers.
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| Free Research Field |
医歯薬学
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