Computational leukemic stem cell models in systems biology for analyses of cell kinetics in leukemic relapse and development of risk-stratified chemotherapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591562
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAIKAWA Yutaka 金沢医科大学, 医学部, 教授 (60283107)
• Co-Investigator(Kenkyū-buntansha): KOMATSUZAKI Toshihiko 金沢大学, 機械工学系, 准教授 (80293372)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 急性骨髄性白血病 / コンピューターシミュレーション / 白血病幹細胞 / システム生物学

Outline of Final Research Achievements

We have constructed a 3-dimentional computer simulation system to investigate the mechanisms of leukemic relapse and develop new risk-stratified treatment protocols. Comparing the cell kinetics of normal hemopoietic stem cells and leukemic stem cells, models of developing leukemias were successfully simulated from a single leukemic stem cells when the cell kinetics of leukemic stem cells was more than 3 times slower than normal hematopoietic stem cells. Subsequently, introducing simulations of chemotherapy, adapted from the AML-05 protocol from Japan Pediatric Leukemia Lymphoma Study Group, into our leukemic models has established a treatment model with 10-year relapse-free survival as a prototype.

Free Research Field

小児血液腫瘍学