Risk of new lethal arrhythmia in School-based Electrocardiographic Screening Programs

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Niigata University
• Principal Investigator: Suzuki Hiroshi 新潟大学, 医歯学総合病院, 特任教授 (00401737)
• Co-Investigator(Kenkyū-buntansha): HOSHINA Satoshi 新潟大学, 医歯学総合病院, 助教 (80444165)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 学校心臓検診 / 致死性不整脈 / 若年突然死

Outline of Final Research Achievements

Short QT Syndrome (SQTS) is characterized by a short QT interval (QTI) and is a cause of sudden death at premature age. QTI were measured in 13948 subjects 12-13 years old in a school-based ECG screening program. 30 subjects with QTI below the 0.25th percentile of the total subjects, were enrolled. We conducted further examination. The mean follow-up period was 2.1 years. 12 of 30 met the SQTS diagnostic criterion proposed in 2013. 5 subjects had a family history of premature sudden death. One was observed with ventricular tachycardia. 3 had an episode of syncope during follow-up period. Among them, one was diagnosed with epilepsy, while the others were diagnosed with neurally mediated syncope. 7 of 12 who met the SQTS diagnostic criterion were observed with normal QTI during follow-up period. Genetic analysis for SQTS genes, did not show any mutations in two subjects. The criteria might overdiagnose SQTS in adolescent population.

Free Research Field

小児循環器