2014 Fiscal Year Annual Research Report
肺高血圧における癌類似の病変形成と退縮の分子細胞機序の解明：新規動物モデルの検討
| Project/Area Number |
24591574
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| Research Institution | Mie University |
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Principal Investigator |
三谷 義英 三重大学, 医学部附属病院, 准教授 (60273380)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 一男 三重大学, 医学(系)研究科(研究院), 教授 (20181828)
澤田 博文 三重大学, 医学(系)研究科(研究院), 講師 (30362354)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 小児循環器学 / 肺高血圧 |
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| Outline of Annual Research Achievements |
１ 新規PAHモデルの確立と病変形成における脱分化平滑筋の関与：Sugen/低酸素モデルにおいて、進行性の肺高血圧、内膜病変、層状病変を認めた。それらの血管病変において、脱分化平滑筋を認め、増殖性、遊走性、マトリックス蛋白産生、プロテアーゼ産生を認めた。Otsuki S, Sawada H, Mitani Y et al.Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.PLoS One. 2015 Feb 25;10(2):e0118655.
２ 新規PAHモデルにおけるエンドセリン受容体拮抗薬の効果：Sugen/低酸素モデルにおけるエンドセリン受容体拮抗薬の効果を早期治療群、８週の後期治療群において検討した。早期治療において肺高血圧と血管病変の改善、後期治療において肺高血圧と血管病変の進行抑制を認めた。Shinohara T, Sawada H, Mitani Y et al.Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.Am J Physiol Lung Cell Mol Physiol. 2015Mar15;308(6):L523-38.
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Research Products
(4 results)
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[Journal Article] Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.2015
Author(s)
Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y.
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Journal Title
PLoS One
Volume: 10(2)
Pages: e0118655
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.2015
Author(s)
Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, Saitoh S, Shimpo H, Maruyama K, Komada Y, Mitani Y.
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Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: 308(6)
Pages: L523-538
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Macitentan Reverses Early Obstructive Pulmonary Vasculopathy in Rats: Early Intervention in Overcoming the Survivin-mediated Resistance to Apoptosis2015
Author(s)
Shinohara T., Sawada H., Otsuki S., Yodoya N., Kato T., Ohashi H., Zhang E., Saitoh S., Shimpo H., Maruyama K., Komada Y., Mitani Y.
Organizer
Association for European Pediatric and Congenital Cardiology
Place of Presentation
Peague, Czech Republic
Year and Date
2015-05-20 – 2015-05-23
Invited
