2014 Fiscal Year Final Research Report
Molecular mechanisms involved in the pathogenesis of occlusive pulmonary vasculopathy
| Project/Area Number |
24591574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Hirofumi 三重大学, 医学(系)研究科(研究院), 講師 (30362354)
MARUYAMA Kazuo 三重大学, 医学(系)研究科(研究院), 教授 (20181828)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 小児科学 / 小児循環器学 / 肺高血圧 / 動物モデル |
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| Outline of Final Research Achievements |
Project 1-Phenotypically Modulated Smooth Muscle Cells and Related Inflammation in the Development of Experimental Obstructive Pulmonary Vasculopathy in Rats -: We tested the hypothesis that phenotypically modulated smooth muscle cells (SMCs) and related inflammation are associated with the progression of experimental occlusive pulmonary vascular disease (PVD). We concluded that phenotypically modulated SMCs and related inflammation are associated with the progression of experimental obstructive PVD.
Project 2-Macitentan reverses early obstructive pulmonary vasculopathy in rats-
We test the hypothesis that a novel endothelin receptor antagonist macitentan reverses the early and/or late stages of occlusive pulmonary vascular disease (PVD) in rats. In conclusion, macitentan reversed early but not late obstructive PVD in rats. This reversal was associated with the suppression of survivin-related resistance to apoptosis and proliferation of cells in PVD.
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| Free Research Field |
医歯薬学
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