Mechanism of arrhythmo-genesis by exercise stress in long QT syndrome patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591575
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: OHNO Seiko 滋賀医科大学, アジア疫学研究センター, 講師 (20610025)
• Co-Investigator(Kenkyū-buntansha): HORIE Minoru 滋賀医科大学, 医学部, 教授 (90183938)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: QT延長症候群 / 不整脈 / 遺伝子変異 / カリウムチャネル / 運動誘発性 / 失神

Outline of Final Research Achievements

Among the long QT syndrome, type 1 and 5 are well known that the symptoms including syncope are related with exercise. The causes of the disease are mutations in KCNQ1 and KCNE1 which encoding slowly activated cardiac potassium ion current channel. Diverse clinical symptoms are depend on the location of the variants. Therefore we analyzed clinical symptoms depend on the mutation locations and performed functional analysis of the mutations using patch clamp methods.

Free Research Field

小児循環器学