2014 Fiscal Year Final Research Report
Establishment of RV heart failure treatment associated brain blood flow
| Project/Area Number |
24591586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本郷 賢一 東京慈恵会医科大学, 医学部, 准教授 (00256447)
角田 亘 東京慈恵会医科大学, 医学部, 准教授 (00453788)
草刈 洋一郎 東京慈恵会医科大学, 医学部, 講師 (80338889)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 右心不全 / 肺動脈 / ミトコンドリア |
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| Outline of Final Research Achievements |
We performed to estimate the effect of RV heart faiure in rats. A release of RV obstructive lesion is important to inhibit progress of fibrosis and brain mitochondrial damage. The progress of fibrosis, and mitochondrial dysfunction were inhibited by the amelioration of the cardiac function, but developed fibrosis was not restored. A PA debanding model might contribute to increased understanding molecular mechanism of the reversibility in heart failure.
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| Free Research Field |
小児循環器学
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