2014 Fiscal Year Final Research Report
| Project/Area Number |
24591612
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SIODA Seiji 昭和大学, 医学部・顕微解剖学教室, 教授 (80102375)
SHIBATO Junko 昭和大学, 医学部・顕微解剖学教室, 研究員 (10611121)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | DOHaD / 網羅的遺伝子解析 / マウス / 新生児期栄養環境変化 / 自然免疫 |
|---|
| Outline of Final Research Achievements |
Although undernutrition during gestation is harmful for fetuses, calorie restriction is a strategy proven to extend healthy and maximum life span after birth. By focusing our attention on genes whose expression oppositely regulated between under- or high-nutrition during neonatal period, we selected candidate genes responsible for DOHaD. The results of microarray in C57BL mouse pup’s liver exposed to neonatal under- (50% food restriction) and high-nutrition (60% high fat food) demonstrated that innate immune system (Fos、Il1b、Rgs1、Ppp1r3g、Hamp、Igll1) was activated shortly after exposure. At weaning, expression of Aldhla 7 was decreased resulting of low resolution of acetaldehyde regardless of the nutritional conditions. By histopathological examination, abnormal development of immune tissues such as thymus and spleen was detected.
|
| Free Research Field |
生殖発生毒性学
|
