2016 Fiscal Year Final Research Report
Corneodesmosomal abnormality in skin barrier defects
| Project/Area Number |
24591620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Research Collaborator |
IGAWA Satomi
Kwasi Teye Kurume University School of Medicine, Department of Dermatology
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | デスモソーム / コルネオデスモソーム / 魚鱗癬 / アトピー性皮膚炎 / コルネオデスモシン / デスモグレイン / LEKTI / カリクレイン |
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| Outline of Final Research Achievements |
Distribution patterns of desmosomal molecules in atopic dermatitis (AD) and related diseases (ichthyosis vulgaris, Netherton syndrome and the inflammation type peeling skin disease (IPSD)) were non-invasively analyzed. The characteristic pattern was obtained in each disease, and it seems to be a useful screening test for IPSD.
Gene analysis of an IPSD patient revealed a complete loss of the corneodesmosin gene due to a founder effect among Japanese patients.
The mechanism for thick AD stratum corneum was studied and incomplete secretion of a desquamation enzyme (KLK7) and increased expression of its inhibitor (LEKTI) were found.
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| Free Research Field |
皮膚科学
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