The role of the skin innate immunity in inflammatory skin diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591622
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: YAMASAKI Kenshi 東北大学, 医学(系)研究科(研究院), 准教授 (40294798)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カセリサイディン / ＩＬ－３６ / 表皮角化細胞 / 自然免疫 / サイトカイン / ケモカイン

Outline of Final Research Achievements

in order to how the innate immune system affect skin inflammatory disease, we examined how cathelicidin affect human epidermal keratinocytes and inflammatory cell in this study. We identified IL-36s, IL-1 family molecules, are induced by the cathelicidin peptide stimulation in human keratinocytes. Cathelicidin and IL-36s are additively or synergisticcally induced inflammatory cytokines in human keratinocytes. We also observed that cathelicidin and IL-36s are coordinately expressed in the lesional epidermis of the psoriasis, a chronic skin inflammatory diseases. These suggested that cathelicidin and IL-36s exacerbate human skin diseases such as psoriasis.

Free Research Field

皮膚科