2014 Fiscal Year Final Research Report
Elucidation of the mechanism by which pemphigus vulgaris autoantibodies cause cellular signaling in human keratinocytes
| Project/Area Number |
24591634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGAMI Jun 慶應義塾大学, 医学部, 講師 (80327618)
AMAGAI Masayuki 慶応義塾大学, 医学部, 教授 (90212563)
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| Research Collaborator |
KOWALCZYK AP 米国エモリー大学, 医学部, 准教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 尋常性天疱瘡 / デスモゾーム / 脂質ラフト / 細胞内シグナル |
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| Outline of Final Research Achievements |
It was shown that desmosomal proteins are biochemically associated with lipid rafts on the human keratinocyte cell membrane. Furthermore, lipid rafts are considered to be an significant platform for both assembly and disassembly of desmosomes. It was also demonstrated that anti-desmoglein (Dsg) 3 autoantibodies in the sera of pemphigus vulgaris patients cause clustering of Dsg3 on the cell surface, and the clustered Dsg3 molecules are to be internalized in a both lipid raft-dependent and cellular signaling-dependent manner.
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| Free Research Field |
自己免疫性水疱症
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