2014 Fiscal Year Final Research Report
Research on the treatment for xeroderma pigmentosum focusing on the oxidarive DNA damage
| Project/Area Number |
24591639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 色素性乾皮症 / コケイン症候群 / 酸化ストレス / ＤＮＡ修復 / 抗酸化 |
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| Outline of Final Research Achievements |
In the present study, we focused on oxidative DNA damage and its repair in the pathogenesis of neurodegeneration in XP and CS patients. Both XP, CS and XP or CS knockdown cells were hypersensitive to killing by hydrogen peroxide and the level of DNA repair ability to oxidative DNA damage estimated by plasmid host cell reactivation in XP and CS cells was decreased compared to that in normal cells. The hypersensitivity to hydrogen peroxide in XP and CS cells slightly ameliorated after the treatment of some antioxidants. In CS mice, the demyelinating change was observed in the cerebral cortex immunohistochemically, as in MRI image of progressive CS cases. These in vitro and in vivo experimental systems would be a useful tool to explore a novel remedy for the neurologic manifestations.
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| Free Research Field |
皮膚科学
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