2014 Fiscal Year Final Research Report
Molecular mechanism of fibrosis : involvement of autocrine TGF-beta signaling.
| Project/Area Number |
24591658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
IHN Hironobu 熊本大学, 生命科学研究部, 教授 (20282634)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 遺伝子 / 細胞・組織 / シグナル伝達 |
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| Outline of Final Research Achievements |
We identified up-regulated or down-regulated genes using DNA microaary analysis and identified up-regulated or down-regulated microRNAs using microRNA array analysis in fibrosis. We made integrin αVβ5 stable transfectants using normal dermal fibroblasts and confirmed overexpression of extracellular matrix genes and down-regulation of proteases, such as MMP-1. We examined the phenotype of fibroblast-specific integrin αV transgenic mice.
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| Free Research Field |
皮膚科学
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