2014 Fiscal Year Final Research Report
Identification of novel atopic dermatitis candidate genes with sequencing analysis against skin barrier associated 200 genes.
| Project/Area Number |
24591665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Akiharu 慶應義塾大学, 医学部, 講師 (70335256)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アトピー性皮膚炎 / エクソーム |
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| Outline of Final Research Achievements |
We established target resequencing method using next generation DNA sequencer for 600 Atopic Dermatitis (AD) related genes, and analyzed against Japanese AD patients. As a result, we isolated 6 candidate AD related mutations including natural immunity and signal pathway in epithelial cells. We analyzed the one candidate mutation against Japanese 150 AD patients among these candidates. Finally, we found the AD patients who show specific dermatitis at face and neck possess this mutation, frequently, and we currently are confirming this result with other Japanese AD patients.
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| Free Research Field |
ゲノム科学
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