Integrated research on brain network dysfunctions and pathogenic factors of panic disorder

2016 Fiscal Year Final Research Report

• Project/Area Number: 24591679
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: Tanii Hisashi 三重大学, 医学系研究科, 准教授 (40346200)
• Research Collaborator: Konishi Yoshiaki ; Tanahashi Shunsuke ; Takase Shinichi
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: パニック症 / 遺伝子多型 / 拡散テンソル画像 / ライフイベント

Outline of Final Research Achievements

Using the 3T MRI apparatus, we carried out diffusion tensor imaging of panic disorder patients and healthy control subjects. We will focus on the thalamus radiation, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the left anterior cingulate gyrus and right posterior cingulate gyrus, which comprise the input/output system of the frontal lobe. We examined representative genetic polymorphisms (COMT Val158Met polymorphism, BDNFval66met polymorphism, Sigma 1 receptor related gene etc), Secondly, factor analysis and principal component analysis were conducted on the results of NEO - PI - R, TCI, STAI and GHQ 12 on the state of anxiety for healthy control volunteers and panic disorder patients. I studied the involvement of genetic factors upon life events and symptoms at panic attack.

Free Research Field

精神医学