The possibilities of activated endogenous neural stem therapy based by imbalanced signal transduction in mood disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagasaki University
• Principal Investigator: OZAWA Hiroki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50260766)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Hirohisa 長崎大学, 病院(医学系), 講師 (10380883) ; KUROTAKI Naohiro 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20423634) ; IMAMURA Akira 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (40325642) ; TATSUMI Rie 長崎大学, 医歯薬学総合研究科(医学系), 助教 (40584727)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 神経幹細胞 / 気分障害 / 培養細胞 / 神経新生 / 変性疾患 / メチルフェデート / ADHD / オメガ３脂肪酸

Outline of Final Research Achievements

The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD) including depression state. We examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).We found that MPH enhanced neuronal differentiation and inhibited neural proliferation. Moreover, ADHDs with depressive state were lower in ω3 fatty acid and modified electroconvulsive therapy for the treatment of refractory schizophrenia-like psychosis associated with Huntington’s disease. Taken together, these results suggest NSC is a key element for a pathophysiology of neuropsychiatric disorders including mood disorders.

Free Research Field

精神神経科学、精神薬理学