2014 Fiscal Year Final Research Report
To realize an etiology of schizophrenia and develop preventable methods of schizophrenia through the mechanism of QT interval prolongation
Project/Area Number |
24591688
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Dokkyo Medical University |
Principal Investigator |
FUJII Kumiko 獨協医科大学, 医学部, 講師 (70314151)
|
Co-Investigator(Kenkyū-buntansha) |
OZEKI Yuji 獨協医科大学, 精神神経医学講座, 准教授 (90303768)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 統合失調症 / QT間隔 |
Outline of Final Research Achievements |
The patients with schizophrenia not receiving antipsychotic treatment had longer QT intervals than the healthy volunteers. The result was published in PLOS ONE. Because KCNH2, NRG1,AKAP9977 and AKAP9978 are the genes which could have relationship with both etiology and QT interval of schizophrenia, mRNA expressions of the genes are measured in patients with schizophrenia and normal controls and the mRNA expressions were compared with QT intervals in patients with schizophrenia. The results were that AKAP9977 mRNA expression was decreased but NRG1 mRNA expression was increased in patients with schizophrenia. There was a relationship between NRG1 and heart rates but no other relationships were found between mRNA expression levels and QT intervals or heart rates.
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Free Research Field |
精神医学
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