Generation of iPS cells from dental pulp of autism patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: Nakayama Atsuo 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 部長 (50227964)
• Co-Investigator(Kenkyū-buntansha): FUKADA Masahide 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 研究員 (80414019)
• Research Collaborator: IIO Akio ; MATSUKI Tohru
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 自閉症 / iPS細胞 / 神経細胞 / 研究リソース / 歯髄細胞

Outline of Final Research Achievements

In order to establish research materials useful for revealing neuronal abnormalities in autistic patient, we have introduced re-programing agents into dental pulp stem cells obtained from 10 autistic patients. During the period, we could established two induced pluripotent stem (iPS) cell clones derived from autistic patients. These iPS cell clones can differentiate into the neuronal lineage expressing several markers for neuronal precursor cells. At this differentiated stage, however, we could not find clear abnormalities in morphology and proliferative potential compared with neuronal precursor cells differentiated from control iPS cells. In spite of the results, we emphasize that these iPS clones derived from autistic patients are useful materials to reveal detailed neuronal abnormalities of autism in future in vitro studies.

Free Research Field

病理学