2014 Fiscal Year Final Research Report
Neuroimaging study of neurobiological effects of cognitive remediation therapy in schizophrenia
| Project/Area Number |
24591712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
PU Shenghong 鳥取大学, 医学部, プロジェクト研究員 (70739789)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 統合失調症 / 認知機能障害 / 認知リハビリテーション / 神経可塑性 / 光トポグラフィー検査 / 背外側前頭前皮質 |
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| Outline of Final Research Achievements |
We investigated twice, 6 months apart, the effects of a cognitive remediation therapy, Neuropsychological Educational Approach to Cognitive Remediation (NEAR), on the cortical hemodynamic responses during two cognitive tasks in the patients with schizophrenia (N=19) using near-infrared spectroscopy (NIRS). NEAR significantly increased the working memory (WM)-related NIRS signal in three cortical regions including frontopolar and dorsolateral prefrontal cortices. There were also significant interactions between “treatment group” and “time” mainly in the forontopolar regions with the increase in the signals being significantly larger in the NEAR group than in the control patient group. In contrast, the verbal fluency-related NIRS signals were generally decreased after NEAR, making a striking difference with the results observed for WM task. These results indicate that NEAR can improve cognitive impairment in schizophrenia in a dynamic way dependent on the task involved.
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| Free Research Field |
精神医学
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