Disrupted cortico-limbic network and molecular mechanism in bipolar disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591716
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUO Koji 山口大学, 医学(系)研究科(研究院), 准教授 (00292912)
• Co-Investigator(Kenkyū-buntansha): YAMGATA Hirotaka 山口大学, 大学院医学系研究科, 助教 (10549934) ; WATANUKI Toshio 山口大学, 医学部附属病院, 助教 (80610865) ; MATSUBARA Toshio 山口大学, 医学部附属病院, 講師 (60526896) ; UCHIDA Shusaku 山口大学, 医学部附属病院, 講師 (10403669) ; OTSUKI Koji 山口大学, 大学院医学系研究科, 助教 (10535256)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 躁うつ病 / 神経画像

Outline of Final Research Achievements

Patients with bipolar disorder (BD) showed decreased frontal activation during emotional words with negative valence. They also showed increased high risk behaviors during a gambling task, which was not associated with gray matter volume of medial prefrontal cortex. Family study demonstrated that patients with BD had small gray matter volume of left insula and the patients and relatives of BD had small gray matter volume of left anterior cingulate.
Depressed patients with BD and depressed and remitted patients with MDD showed increased level of mRNA expression of hypoxia-inducible factor-1.

Free Research Field

精神医学