A biological basis of neurocognitive impairment in mood disorder patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: MIURA Tomofumi 九州大学, 大学病院, 助教 (90404053)
• Co-Investigator(Kenkyū-buntansha): MOTOMURA Keisuke 九州大学, 大学病院, 助教 (60432944)
• Co-Investigator(Renkei-kenkyūsha): KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187) ; ONITSUKA Toshiaki 九州大学, 医学研究院, 准教授 (00398059)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 気分障害 / 双極性障害 / 認知機能 / MCCB-J / エピジェネティクス

Outline of Final Research Achievements

In this study, we measured neurocognitive function in bipolar disorder patients and in healthy controls with the standard neurocognitive battery, named Japanese version of MCCB (MCCB-J), and we elucidated the characteristics of cognitive deficits in bipolar patients. We also found that the MCCB-J as well as other language version of MCCB could be useful to evaluate neurocognitive deficits in bipolar disorder. Next, we analyzed whole genomic methylation pattern of DNA derived from peripheral mono-nuclear cell and identified 50 candidate sites for methylation biomarker of bipolar disorder and several differentially methylated sites that related to specific neurocognitive function. This is the first study that evaluate characteristics of neurocognitive function in Japanese bipolar patients with a standard cognitive battery. This study can provide useful basic information about neurocognitive deficits in Japanese bipolar patients.

Free Research Field

精神医学