A Study of Therapeutic Mechanism of rTMS for Cognitive Dysfunction of Schizophrenia by Evaluation of GABAergic Function

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591727
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Wakayama Medical University
• Principal Investigator: UKAI Satoshi 和歌山県立医科大学, 医学部, 准教授 (80324763)
• Co-Investigator(Kenkyū-buntansha): SHINOSAKI Kazuhiro 和歌山県立医科大学, 医学部, 教授 (40215984) ; TSUJI Tomikimi 和歌山県立医科大学, 医学部, 講師 (10347586) ; TAKAHASHI Shun 和歌山県立医科大学, 医学部, 助教 (10508021) ; YAMAMOTO Masahiro 和歌山県立医科大学, 医学部, 助教 (80423937) ; SAKAMOTO Yuka 和歌山県立医科大学, 医学部, 助教 (90423938) ; KISE Asami 和歌山県立医科大学, 医学部, 助教 (10405425) ; OKUMURA Masatoshi 和歌山県立医科大学, 医学部, 助教 (00464678) ; UEYAMA EIKO 和歌山県立医科大学, 医学部, 助教 (40405444) ; HASHIMOTO Tadahiro 和歌山県立医科大学, 医学部, 学内助教 (00438277) ; OSAWA Kyoko 和歌山県立医科大学, 医学部, 学内助教 (50612107)
• Co-Investigator(Renkei-kenkyūsha): UEYAMA Keiji 和歌山県立医科大学, 医学部, 教授 (50264875) ; KANEOKE Yoshiki 和歌山県立医科大学, 医学部, 教授 (20280589) ; HOTOMI Muneki 和歌山県立医科大学, 医学部, 准教授 (90336892) ; IWATANI Jun ; ISHIDA Takuya ; SHOYAMA Masaru
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 統合失調症 / 認知機能 / 磁気刺激療法 / GABA

Outline of Final Research Achievements

Repetitive transcranial magnetic stimulation (rTMS), a new therapeutic method for depression, is studied for application of treatment of cognitive dysfunction of schizophrenia. On the other hand, its cognitive dysfunction is supposed to relate with cortical GABAergic dysfunction. In this study, we aimed to examine therapeutic mechanisms and their evidences of this rTMS treatment by complementarily using paired-pulse transcranial magnetic stimulation that can evaluate cortical GABAergic function, real-time cortical blood flow responsivity to rTMS, and several functional/structural neuroimaging techniques. Due to the time shortage, we did not reach the final stage to conduct rTMS treatment in parallel with these measurements within this study period. However, using these measurements and techniques, we obtained several important results those can contribute to clarify pathophysiology of neuropsychiatric diseases including schizophrenia.

Free Research Field

臨床精神医学