2014 Fiscal Year Final Research Report
Functional role of the N-terminal domain of DFosB in response to stress and drugs of abuse.
| Project/Area Number |
24591735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHI Akinori 久留米大学, 医学部, 教授 (50228144)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | うつ病 / コカイン依存症 / FosB / 転写因子 / 行動実験 / 側坐核 / AP-1 |
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| Outline of Final Research Achievements |
DFosB is transcriptional factor, which is accumulated in specific brain regions by chronic or repeated stimulation of stress or addictive drugs. We have reported DFosB makes a role for anti-depressant. However, overexpressed DFosB mRNA codes DFosB and N-terminal lacking D2DFosB, and expresses at similar level. We tried to reveal which one has more important role for depression and cocaine addiction by respective expression using AAV in nucleus accumbens. In results, DFosB enhanced cocaine addiction after social defeat stress, and works as anti-depressant, but, D2DFosB inhibit such type of cocaine addiction and does not work as anti-depressant.
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| Free Research Field |
分子神経科学
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