A prospective study on the pathophysiology and therapy of delirium

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591736
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: NAKAMURA Jun 産業医科大学, 医学部, 教授 (40148804)
• Co-Investigator(Kenkyū-buntansha): SUGITA Atsuko 産業医科大学, 医学部, 助教 (40421333) ; HORI Hikaru 産業医科大学, 医学部, 助教 (50421334) ; YOSHIMURA Reiji 産業医科大学, 医学部, 准教授 (90248568)
• Co-Investigator(Renkei-kenkyūsha): IGATA Ryouhei 産業医科大学, 医学部, 産業医学修練医 (00739477)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 術後せん妄 / 前向き研究 / リエゾン精神医学 / BDNF

Outline of Final Research Achievements

We performed the prospective randomized control study regarding the efficacy of psychological intervention for preventing post-operative delirium, and also investigated the reliability and validity of the delirium rating scale (DRS-R-98) in Japanese version. Patients who operated in liver, bile duct, and pancreas disease were enrolled the study. The patients were randomized in two groups (intervention and non-intervention). The scores of the DRS-R-98, BMI value, plasma levels of catecholamine metabolites, BDNF, and cytokines were compared between the two groups. Higher age, lower BMI, were definitely associated with the occurrence of delirium. There was a tendency lower BDNF and higher MHPG at baseline were related with delirium. Brief psychological intervention could not prevent emerging delirium. The validity and the reliability of the DRS-R-98 were robust. From these findings into account, more intensive psychological intervention is necessary to prevent post-operative delirium.

Free Research Field

精神医学