Optimization of voxel-based statistical analyses for amyloid PET of Alzheimer's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: KANETA Tomohiro 東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (50323019)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Nobuyuki 東北大学, 医学(系)研究科(研究院), 准教授 (40361076)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アミロイドイメージング / 統計画像解析 / PET

Outline of Final Research Achievements

We performed voxel-based statistical analyses for amyloid PET with BF-227 using both SPM and 3D-SSP, and compared the results in order to explore the optimal methods for the analyses. Differences in results were seen in 24% of normal subjects, 45% of MCI patients, and 68% of AD patients. Errors were often seen in the results of anatomical standardization. The use of blood flow images for 3D-SSP, and scalping for SPM might enable to reduce errors.

Free Research Field

放射線科学