2014 Fiscal Year Final Research Report
Analysis of anemia associated with patients treated by interfern and ribavirin
| Project/Area Number |
24591749
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 大気マイクロＰＩＸＥ / 赤血球 / Ｃ型慢性肝炎 |
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| Outline of Final Research Achievements |
Since interferon + ribavirin (2 agent therapy) and interferon + ribavirin + telaprevir (3 agent therapy) are introduced as a specific therapy for chronic hepatitis C, the sustained viral response was markedly increased; whereas drug-induced anemia was frequently complicated. We elucidated the pathogenesis of this anemia using in-air microPIXE. In healthy control, the rods of Cl, S, and K were distributed over the peripheral area of erythrocytes, so-called the donut-like appearance. These elements tended to aggregate partially and distribute patchily on the erythrocytes obtained from patients received the interferon mono-therapy. The patchily aggregation of each element became indistinct on the erythrocytes from patients received 2 or 3 agent therapy. The findings suggest that the disturbance of elemental distribution may participate into the anemia complicated with 2 or 3 agent therapy.
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| Free Research Field |
消化器病
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