Imaging study on receptor binding, cerebral blood flow and metabolism in diabates mouse brain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: HOSOI Rie 大阪大学, 医学(系)研究科(研究院), 助教 (30291446)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病 / 脳循環代謝 / FDG / 酢酸 / 乳酸 / 受容体結合

Outline of Final Research Achievements

Glial energy metabolism in both type 1 and type 2 diabetic model mouse brain was measured with 14C-acetate. 14C-acetate uptake was significantly increased in diabetic model mouse brain. 18F-FDG, a glucose analog, uptake at 1 minute and 30 minutes after 18F-FDG injection was decreased. 18F-FDG uptake (30 minutes) was more sensitive, and it shows that phosphorylation process by hexokinase is more sensitive than transport process by glucose transporters. In type 2 diabetic model brain, 14C-lactate uptake was significantly increased. It is suggested the possibility that energy substrates shifted to alternative one, such as monocarboxylates in diabetic model mouse brain.
In vivo muscarinic acetylcholine receptor binding using 3H-QNB was partly decreased. However, future study is required about receptor binding in diabetic model animal brain.

Free Research Field

医歯薬学