MRI evaluation of the globus pallidus lesion in progressive supranuclear palsy including pathological proved cases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University (2014); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2012-2013)
• Principal Investigator: SAKURAI Keita 名古屋市立大学, 医学(系)研究科(研究院), 講師 (70453066)
• Co-Investigator(Kenkyū-buntansha): TOKUMARU Aya 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 研究員 (60507391)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Susumu 名古屋市立大学, 大学院医学研究科, 研究員 (70596949)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 進行性核上性麻痺 / 多系統萎縮症 / パーキンソン症候群 / 画像統計解析

Outline of Final Research Achievements

In the first year of this study, we have evaluated the globus pallidus lesion of pathologically proved patients with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). Compared with DLB patients, PSP patients (57%) have revealed more clearly the characteristic high signal intensities in the globus pallidus on T2-weithted image. In spite of small number of the patients, this high signal intensity is thought to be useful for the diagnosis of PSP. Second and third year in this study, we have used the voxel-based analysis of cerebral volume and blood flow for the diagnosis of PSP, corticobasal syndrome, multiple system atrophy and Parkinson disease. These results have proved that white matter volume decrease of the precentral gyrus and hypoperfusion of the cerebellum are useful for the differentiation of these disorders.

Free Research Field

放射線画像診断学