Brain stroke validation from diffusion weighed image of twice-refocused spin-echo sequence

2016 Fiscal Year Final Research Report

• Project/Area Number: 24591801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: 秋田県立脳血管研究センター(研究部門)
• Principal Investigator: Nakamura Kazuhiro 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (10312638)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 脳・神経 / 放射線 / 核磁気共鳴画像 / 拡散強調画像 / 脳卒中

Outline of Final Research Achievements

Typical single refocused pulsed-gradient spin-echo (SRSE-DWI) sequence is interacted by susceptibility-induced background gradient fields around vessels, while twice-refocused spin-echo (TRSE-DWI) sequence is reduced the effect. The difference between SRSE-DWI and TRSE-DWI will indicate CBV weighted image. We evaluated the ADC reduced ratio in both sequence with computer simulations in a vascular model. We made TRSE-DWI sequence for animal MRI and evaluated on stroke model rats. The simulation results indicate possible criteria for brain stroke validation. The experimental results did not show adequate S/N images. At this moment, we now evaluating the images from normal volunteer and stroke patients.

Free Research Field

生体医工学