Evaluation of Insulin Independence using 11C -Methionine Positron Emission Tomography after Living-donor and Brain-dead Donor Pancreas Transplantation

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Clinical research Center, Chiba-East National Hospital, National Hospital Organization
• Principal Investigator: otuki kazunori 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (50399755)
• Co-Investigator(Kenkyū-buntansha): AKUTSU naotake 千葉東病院臨床研究センター, 移植医療再生部長 (00344979) ; MARUTAMA michihiro 千葉東病院臨床研究センター, 移植医療再生部長 (00344979) ; KENMOCHI takashi 千葉東病院臨床研究センター, 臨床研究センター長 (00344979) ; ITO taihei 千葉東病院臨床研究センター, 研究員 (00344979)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: pet

Outline of Final Research Achievements

The objective of this study was to evaluate the post-operative insulin independence in 10 living donor (LD) and 10 brain-dead donor (BD) pancreas transplantations for 20 patients with type I diabetes mellitus by using 11C-methionine PET. Patient survivals were 100% at 5 years for LD transplants and at 2 years for BD transplants. The SUVs of LD and BD pancreas transplants with insulin independence were 7.2 ± 1.8 and 10.4 ± 2.3, respectively. The SUVs of LD pancreas transplants with insulin dependence and BD pancreas transplants with graft failure were 3.6 ± 1.1 and 2.9 ± 1.0, respectively. At 5 years after transplantation, for the LD transplants, the insulin-independent rate was 100% for the graft recipients with an SUV higher than 5, and the median insulin independence duration of the graft recipients with an SUV lower than 5 was 7 month (p < 0.01). The 11C-methionine PET may be a potent modality to predict long-term insulin independence and the avoidance of pancreas graft failure.

Free Research Field

外科