Development and application of radiometal-octabromoporphyrin as a tumor imaging agent

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KITAMURA Yoji 金沢大学, 学際科学実験センター, 准教授 (10368483)
• Co-Investigator(Kenkyū-buntansha): OGAWA Kazuma 金沢大学, 新学術創成研究機構, 准教授 (30347471)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射性医薬品 / ポルフィリン / 腫瘍 / 錯体

Outline of Final Research Achievements

In this study, a new radiometal-octabromoporphyrines was developed and the possibililty of application for a new tumor imaging agent was examined. As a result, it was found that Octabromotetrakis (4-carboxyphenyl)porphine（OBTCPP） could be radiolabelled by 111In, a radio nuclear for diagnosis, in short times. It was also found that, in tumor bearing mice which transplanted NB2a tumor cell or KLN205 tumor cell, 111In-OBTCPP was accumulated in both tumors at about 4% dose/g, and tumor to muscle ratio was over 10 in the tumors.

Free Research Field

放射性医薬品