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2014 Fiscal Year Final Research Report

Significance of gadoxetic acid-enhanced MR imaging signal intensity for predicting the efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

Research Project

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Project/Area Number 24591814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

FUJITA Nobuhiro  九州大学, 大学病院, 助教 (30610612)

Co-Investigator(Kenkyū-buntansha) NISHIE Akihiro  九州大学, 医学(系)研究科(研究院), 講師 (20457427)
ASAYAMA Yoshiki  九州大学, 大学病院, 講師 (40380414)
USHIJIMA Yasuhiro  九州大学, 医学(系)研究科(研究院), 助教 (40432934)
TAKAYAMA Yukihisa  九州大学, 医学(系)研究科(研究院), 助教 (60546563)
HONDA Hiroshi  九州大学, 医学(系)研究科(研究院), 教授 (90145433)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords肝細胞癌 / MRI / Gd-EOB-DTPA / 肝動注化学療法
Outline of Final Research Achievements

The purpose of the present study was to clarify the relationship in hepatocellular carcinoma cases between the tumor signal intensity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging and the patient response to hepatic arterial infusion chemotherapy. The higher intensity group in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging showed a significantly higher progression-free survival rate than the lower intensity group. Patients with HCCs of higher intensity in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging can respond better to hepatic arterial infusion chemotherapy.

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Published: 2016-06-03  

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